Pyroptosis - A cell death modality of its kind? Review uri icon

Overview

MeSH Major

  • Cell Death
  • Inflammation
  • Macrophages
  • Multiprotein Complexes

abstract

  • The term "pyroptosis" was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis - which can also be triggered by non-bacterial pathological stimuli - truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.

publication date

  • March 2010

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/eji.200940160

PubMed ID

  • 20201017

Additional Document Info

start page

  • 627

end page

  • 30

volume

  • 40

number

  • 3