MYC regulation of a "poor-prognosis" metastatic cancer cell state Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Breast Neoplasms
  • Gene Expression Regulation, Neoplastic
  • Proto-Oncogene Proteins c-myc

abstract

  • Gene expression signatures are used in the clinic as prognostic tools to determine the risk of individual patients with localized breast tumors developing distant metastasis. We lack a clear understanding, however, of whether these correlative biomarkers link to a common biological network that regulates metastasis. We find that the c-MYC oncoprotein coordinately regulates the expression of 13 different "poor-outcome" cancer signatures. In addition, functional inactivation of MYC in human breast cancer cells specifically inhibits distant metastasis in vivo and invasive behavior in vitro of these cells. These results suggest that MYC oncogene activity (as marked by "poor-prognosis" signature expression) may be necessary for the translocation of poor-outcome human breast tumors to distant sites.

publication date

  • February 23, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2840447

Digital Object Identifier (DOI)

  • 10.1073/pnas.0914203107

PubMed ID

  • 20133671

Additional Document Info

start page

  • 3698

end page

  • 703

volume

  • 107

number

  • 8