Clinical findings in MuSK-antibody positive myasthenia gravis: a U.S. experience Academic Article uri icon


MeSH Major

  • Myasthenia Gravis
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Cholinergic


  • We performed a retrospective chart review on 53 muscle-specific kinase antibody (MuSK-Ab)-positive myasthenia gravis (MG) patients at nine university-based centers in the U.S. Of these, 66% were Caucasian, 85% were women, and age of onset was 9-79 years. Twenty-seven patients were nonresponsive to anticholinesterase therapy. Myasthenia Gravis Foundation of America improvement status was achieved in 53% patients on corticosteroids, 51% with plasma exchange, and in 20% on intravenous immunoglobulin (IVIG). Thymectomy was beneficial in 7/18 patients at 3 years. Long-term (> or =3 years) outcome was very favorable in 58% of patients who achieved remission and/or minimal manifestation status. Overall, 73% improved. There was one MG-related death. This survey reinforces several cardinal features of MuSK-Ab-positive MG, including prominent bulbar involvement and anticholinesterase nonresponsiveness. Facial or tongue atrophy was rare. Most patients respond favorably to immunotherapy. The best clinical response was to corticosteroids and plasma exchange, and the poorest response was to IVIG. Long-term outcome is favorable in about 60% of cases.

publication date

  • March 2010



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1002/mus.21533

PubMed ID

  • 19882635

Additional Document Info

start page

  • 370

end page

  • 4


  • 41


  • 3