Application of immunohistochemistry to the diagnosis of kidney tumors Report uri icon


MeSH Major

  • Adenocarcinoma
  • Carcinoma, Squamous Cell
  • Carcinoma, Transitional Cell
  • Neoplasms, Multiple Primary
  • Urologic Neoplasms


  • Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors. © 2010 by Lippincott Williams & Wilkins.

publication date

  • January 2010



  • Report


Digital Object Identifier (DOI)

  • 10.1097/PCR.0b013e3181d51c70

Additional Document Info

start page

  • 25

end page

  • 34


  • 15


  • 1