RIP kinases initiate programmed necrosis Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Necrosis
  • Receptor-Interacting Protein Serine-Threonine Kinases

abstract

  • Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic details, however, remain controversial.

publication date

  • December 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1093/jmcb/mjp007

PubMed ID

  • 19679643

Additional Document Info

start page

  • 8

end page

  • 10

volume

  • 1

number

  • 1