Amplification of epidermal growth factor receptor gene in renal cell carcinoma
Carcinoma, Renal Cell
Gene Expression Regulation, Neoplastic
Receptor, Epidermal Growth Factor
Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.