Amplification of epidermal growth factor receptor gene in renal cell carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Gene Amplification
  • Gene Expression Regulation, Neoplastic
  • Kidney Neoplasms
  • Receptor, Epidermal Growth Factor

abstract

  • Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.

publication date

  • March 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ejca.2010.01.011

PubMed ID

  • 20167476

Additional Document Info

start page

  • 859

end page

  • 62

volume

  • 46

number

  • 5