Harnessing human dendritic cell subsets for medicine Review uri icon

Overview

MeSH Major

  • Adaptive Immunity
  • Dendritic Cells
  • Immunity, Innate
  • Immunotherapy
  • Vaccines

abstract

  • Immunity results from a complex interplay between the antigen-non-specific innate immune system and the antigen-specific adaptive immune system. The cells and molecules of the innate system employ non-clonal recognition receptors including lectins, Toll-like receptors, NOD-like receptors, and helicases. B and T lymphocytes of the adaptive immune system employ clonal receptors recognizing antigens or their derived peptides in a highly specific manner. An essential link between innate and adaptive immunity is provided by dendritic cells (DCs). DCs can induce such contrasting states as immunity and tolerance. The recent years have brought a wealth of information on the biology of DCs revealing the complexity of this cell system. Indeed, DC plasticity and subsets are prominent determinants of the type and quality of elicited immune responses. In this article, we summarize our recent studies aimed at a better understanding of the DC system to unravel the pathophysiology of human diseases and design novel human vaccines.

publication date

  • March 2010

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2847489

Digital Object Identifier (DOI)

  • 10.1111/j.0105-2896.2009.00884.x

PubMed ID

  • 20193020

Additional Document Info

start page

  • 199

end page

  • 212

volume

  • 234

number

  • 1