The Daughterless N-terminus directly mediates synergistic interactions with Notch transcription complexes via the SPS+A DNA transcription code Academic Article uri icon


MeSH Major

  • Dopamine
  • Early Growth Response Protein 1
  • Gene Expression Regulation
  • Neurons
  • Olfactory Bulb


  • These findings indicate that direct physical interactions between Da-N and Su(H) are critical for the transcriptional synergy between NTC and bHLH A proteins on the m8 promoter. Our results also indicate that the orientation of the Su(H) binding sites in the SPS+A transcription code are critical for programming the interaction between Da-N and Su(H) proteins. Together, these findings provide insight into the molecular mechanisms by which the NTC synergistically interacts with bHLH A proteins to mediate Notch target gene expression in proneural clusters.

publication date

  • December 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC2686717

Digital Object Identifier (DOI)

  • 10.1186/1756-0500-2-65

PubMed ID

  • 19400956

Additional Document Info

start page

  • 65


  • 2