Vascular endothelial growth factor inhibits bone morphogenetic protein 2 expression in rat mesenchymal stem cells Academic Article uri icon

Overview

MeSH Major

  • Bone Morphogenetic Protein 2
  • Mesenchymal Stromal Cells
  • Vascular Endothelial Growth Factor A

abstract

  • VEGF is a potent inhibitor of BMP2 expression in MSCs, and supplementation or overexpression of VEGF inhibits osteogenesis in vitro and ectopic bone formation in vivo. Strategies to utilize MSCs in bone tissue engineering therefore require careful optimization and precise delivery of growth factors for maximal bone formation.

publication date

  • February 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2947933

Digital Object Identifier (DOI)

  • 10.1089/ten.tea.2009.0426

PubMed ID

  • 19754224

Additional Document Info

start page

  • 653

end page

  • 62

volume

  • 16

number

  • 2