Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: Analytical validation of ELISA based assays and characterization at mRNA and protein levels Academic Article uri icon

Overview

MeSH Major

  • Membrane Glycoproteins
  • Mesothelioma
  • Osteopontin
  • Peptide Fragments

abstract

  • These assays provide reliable and reproducible quantitation of SMRP and OPN proteins. Both are increased in mesothelioma patients compared to non-mesothelioma controls. However, the two analytes do not correlate with each other and show distinct expression profiles and protein expression. Concentrations of SMRP but not OPN are decreased in post-surgical samples. Our results further characterize these markers, establish assay performance characteristics, and lay the groundwork for further studies to measure these markers in blood.

publication date

  • February 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1515/CCLM.2010.066

PubMed ID

  • 20131968

Additional Document Info

start page

  • 271

end page

  • 8

volume

  • 48

number

  • 2