Systemic sclerosis and lupus: Points in an interferon-mediated continuum
Gene Expression Profiling
Lupus Erythematosus, Systemic
SLE and SSc fit within the same spectrum of IFN-mediated diseases. A subset of SSc patients shows a "lupus-like" high IFN-inducible gene expression pattern that correlates with the presence of antitopoisomerase and anti-U1 RNP antibodies.