Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury Academic Article uri icon

Overview

MeSH Major

  • HMGB1 Protein
  • Liver
  • Reperfusion Injury
  • Toll-Like Receptor 9

abstract

  • TLR9 serves as an endogenous sensor of tissue necrosis that exacerbates the innate immune response during liver I/R. Combined blockade of TLR9 and HMGB1 represents a clinically relevant, novel approach to limiting I/R injury.

publication date

  • February 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3164814

Digital Object Identifier (DOI)

  • 10.1002/hep.23365

PubMed ID

  • 19902481

Additional Document Info

start page

  • 621

end page

  • 32

volume

  • 51

number

  • 2