Obesity and breast cancer: Progress to understanding the relationship Review uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Obesity
  • Signal Transduction

abstract

  • Epidemiological evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase (AMPK) is recognized to be a master regulator of energy homeostasis. One of its actions is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2). In postmenopausal women, the CREB-dependent regulation of aromatase is a crucial determinant of breast tumor formation through local production of estrogens. We report here that the regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.

publication date

  • January 2010

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-09-2257

PubMed ID

  • 20028864

Additional Document Info

start page

  • 4

end page

  • 7

volume

  • 70

number

  • 1