Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Academic Article uri icon

Overview

MeSH

  • Animals
  • Disease Progression
  • Humans
  • Neoplastic Stem Cells
  • Neovascularization, Pathologic

MeSH Major

  • Angiogenesis Inhibitors
  • Endothelium, Vascular
  • Growth Substances
  • Neoplasms

abstract

  • The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.

publication date

  • February 2010

has subject area

  • Angiogenesis Inhibitors
  • Animals
  • Disease Progression
  • Endothelium, Vascular
  • Growth Substances
  • Humans
  • Neoplasms
  • Neoplastic Stem Cells
  • Neovascularization, Pathologic

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2944775

Digital Object Identifier (DOI)

  • 10.1038/nrc2791

PubMed ID

  • 20094048

Additional Document Info

start page

  • 138

end page

  • 146

volume

  • 10

number

  • 2