Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors Article uri icon

Overview

MeSH Major

  • Angiogenesis Inhibitors
  • Endothelium, Vascular
  • Growth Substances
  • Neoplasms

abstract

  • The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.

publication date

  • February 2010

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1038/nrc2791

Additional Document Info

start page

  • 138

end page

  • 46

volume

  • 10

number

  • 2