Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology Academic Article uri icon


MeSH Major

  • Alzheimer Disease
  • Amyloid
  • Brain
  • Cognition Disorders
  • Positron-Emission Tomography


  • Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro. In this study, phosphorylated tau (P-tau) and total tau (T-tau) were measured before and after 6 month treatment with memantine in 12 subjects ranging from normal cognition with subjective memory complaints, through mild cognitive impairment to mild Alzheimer's disease. Thirteen non-treated individuals served as controls. Treatment was associated with a reduction of P-tau in subjects with normal cognition. No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group. © 2009-IOS Press.

publication date

  • January 2009



  • Academic Article


Digital Object Identifier (DOI)

  • 10.3233/JAD-2009-1183

Additional Document Info

start page

  • 509

end page

  • 513


  • 18


  • 3