IKK connects autophagy to major stress pathways Academic Article uri icon

Overview

MeSH Major

  • Surgical Instruments
  • Sutures

abstract

  • Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFkappaB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IkappaB kinase) complex, which is critical for the stress-elicited activation of NFkappaB, is sufficient to promote autophagy independent of NFkappaB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.

publication date

  • January 2010

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.4161/auto.6.1.10818

Additional Document Info

start page

  • 189

end page

  • 91

volume

  • 6

number

  • 1