Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back Article uri icon

Overview

MeSH Major

  • MAP Kinase Signaling System
  • ras Proteins

abstract

  • The RASopathies are a group of genetic syndromes caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Some of these syndromes are neurofibromatosis type 1, Noonan syndrome, Costello syndrome, cardio-facio-cutaneous syndrome, LEOPARD syndrome and Legius syndrome. Their common underlying pathogenetic mechanism brings about significant overlap in phenotypic features and includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium "Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back" chronicle the timely and typical research symposium which brought together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras syndromes and their families. The goals, to discuss basic science and clinical issues, to set forth a solid framework for future research, to direct translational applications towards therapy and to set forth best practices for individuals with RASopathies were successfully meet with a commitment to begin to move towards clinical trials.

authors

publication date

  • January 2010

Research

keywords

  • Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4051786

Digital Object Identifier (DOI)

  • 10.1002/ajmg.a.33183

PubMed ID

  • 20014119

Additional Document Info

start page

  • 4

end page

  • 24

volume

  • 152

number

  • 1