Use of epidermal growth factor receptor/kirsten rat sarcoma 2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung adenocarcinomas: Comparison with clinical guidelines Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • DNA, Neoplasm
  • Lung Neoplasms
  • Mutation
  • Neoplasms, Multiple Primary
  • Proto-Oncogene Proteins
  • Receptor, Epidermal Growth Factor
  • ras Proteins

abstract

  • Assuming that independent tumor clones harbor distinct mutations, these seven cases highlight discrepancies between the existing clinical criteria used to distinguish independent tumor foci from metastases. EGFR/KRAS mutation testing of multiple lung adenocarcinomas can assist in differentiating multiple primary lung adenocarcinomas from metastatic lesions. Use of CHS in this setting should also be further explored.

publication date

  • January 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1378/chest.09-0325

PubMed ID

  • 19376842

Additional Document Info

start page

  • 46

end page

  • 52

volume

  • 137

number

  • 1