Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Eukaryotic Initiation Factor-4E
  • Lung Neoplasms
  • Proto-Oncogene Proteins c-akt

abstract

  • This study shows that p-eIF4E expression in addition to p-AKT predicts poor prognosis in NSCLC. Moreover, the correlation between expression of p-eIF4E with p-AKT, as well as p-TSC2 and p-S6, indicates that eIF4E activation through the AKT pathway plays an important role in the progression of NSCLC.

publication date

  • January 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-09-0986

PubMed ID

  • 20008839

Additional Document Info

start page

  • 240

end page

  • 8

volume

  • 16

number

  • 1