Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer
Carcinoma, Non-Small-Cell Lung
Eukaryotic Initiation Factor-4E
Proto-Oncogene Proteins c-akt
This study shows that p-eIF4E expression in addition to p-AKT predicts poor prognosis in NSCLC. Moreover, the correlation between expression of p-eIF4E with p-AKT, as well as p-TSC2 and p-S6, indicates that eIF4E activation through the AKT pathway plays an important role in the progression of NSCLC.