HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
Neoplastic Stem Cells
T-Cell Antigen Receptor Specificity
Gene transfer allows the reliable generation of HER2-specific T cells from GBM patients, which have potent antitumor activity against autologous HER2-positive tumors including their putative stem cells. Hence, the adoptive transfer of HER2-redirected T cells may be a promising immunotherapeutic approach for GBM.