HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Glioblastoma
  • Neoplastic Stem Cells
  • Receptor, ErbB-2
  • T-Cell Antigen Receptor Specificity
  • T-Lymphocytes, Cytotoxic

abstract

  • Gene transfer allows the reliable generation of HER2-specific T cells from GBM patients, which have potent antitumor activity against autologous HER2-positive tumors including their putative stem cells. Hence, the adoptive transfer of HER2-redirected T cells may be a promising immunotherapeutic approach for GBM.

publication date

  • January 15, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3682507

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-09-1322

PubMed ID

  • 20068073

Additional Document Info

start page

  • 474

end page

  • 85

volume

  • 16

number

  • 2