Interstitial infusion of erlotinib in the rodent brain Academic Article uri icon

Overview

MeSH Major

  • Quinazolines
  • Receptor, Epidermal Growth Factor

abstract

  • A critical need exists for the development of novel forms of treatment for high-grade glioma. Molecular characterization of high-grade glioma has shown overexpression of the epidermal growth factor receptor, antagonists to which, including erlotinib, may prevent tumor growth. Interstitial infusion is a mode of local delivery which bypasses the blood-brain barrier and utilizes a pressure-dependent gradient to enhance drug uniformity and volume of distribution. Interstitial infusion of erlotinib was performed to the striatum of 12 rats in increasing, therapeutic doses. No evidence of clinical or histopathologic toxicity was found. In this experimental study we demonstrate that interstitial infusion of erlotinib is safe in the rodent brain, and may have potential applicability for the treatment of high-grade glioma.

publication date

  • December 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 20192114

Additional Document Info

start page

  • 79

end page

  • 84

volume

  • 8

number

  • 2