Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold? Article Report uri icon

Overview

MeSH Major

  • Brain
  • Cognition
  • Magnetic Resonance Imaging
  • Persistent Vegetative State

abstract

  • In the absence of "hard" neurophysiologic markers, the burden of proof for establishing conscious awareness in individuals who sustain severe brain injury lies in behavioral assessment. Because behavior represents indirect evidence of consciousness, reliance on behavioral markers presents significant challenges and may lead to misdiagnosis. Detection of conscious awareness is confounded by numerous factors including fluctuations in arousal level, difficulty differentiating reflexive or involuntary movement from intentional behavior, underlying sensory and motor impairments, and medication side effects. When an ambiguous behavior is observed, the onus falls to the clinician to determine where along the continuum of unconsciousness to consciousness, it lies. This paper (1) summarizes the current diagnostic criteria for coma, the vegetative state, and the minimally conscious state, (2) describes current behavioral assessment methods, (3) discusses the limitations of behavioral assessment techniques, (4) reviews recent applications of functional neuroimaging in the assessment of patients with disorders of consciousness, and (5) concludes with a case study that illustrates the disparity between behavioral and functional neuroimaging findings that may be encountered in this population.

publication date

  • December 2009

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0079-6123(09)17704-X

PubMed ID

  • 19818893

Additional Document Info

start page

  • 33

end page

  • 48

volume

  • 177

number

  • C