Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure Academic Article uri icon

Overview

MeSH Major

  • Autonomic Nervous System
  • Blood Pressure
  • Dopamine beta-Hydroxylase
  • Genetic Predisposition to Disease
  • Hypertension
  • Polymorphism, Single Nucleotide

abstract

  • These results suggest that common DBH promoter variant C-970T plays a role in the pathogenesis of human essential hypertension: common genetic variation in the DBH promoter region seems to initiate a cascade of biochemical and physiological changes eventuating in alterations of basal BP. These observations suggest new molecular strategies for probing the pathophysiology, risk, and rational treatment of systemic hypertension.

publication date

  • January 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2860271

Digital Object Identifier (DOI)

  • 10.1097/HJH.0b013e328332bc87

PubMed ID

  • 20009769

Additional Document Info

start page

  • 76

end page

  • 86

volume

  • 28

number

  • 1