Sertraline improves executive function in patients with vascular cognitive impairment Academic Article uri icon

Overview

MeSH Major

  • Dementia, Vascular
  • Depressive Disorder
  • Executive Function
  • Sertraline

abstract

  • The authors reviewed 35 open-label sertraline trials for executive impairment in ischemic cerebrovascular disease. Outcomes included clock-drawing, the Executive Interview (EXIT25), the Geriatric Depression Scale, and the Mini-Mental State Examination. Clinically "meaningful" improvement was defined as a >3.0 EXIT25 point decline from baseline. "Remission" was defined as the achievement of an EXIT25 score <15/50. Only EXIT25 scores improved significantly. Twenty patients (57.1%) experienced a clinically meaningful improvement in executive control function. Twelve (34.3%) achieved remission. Our findings suggest that sertraline may have both statistical and clinically meaningful effects on executive control function in ischemic cerebrovascular disease. The authors discuss the implications for future clinical trials.

publication date

  • September 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1176/appi.neuropsych.21.4.445

PubMed ID

  • 19996254

Additional Document Info

start page

  • 445

end page

  • 54

volume

  • 21

number

  • 4