Transforming growth factor beta and excess burden of renal disease. Academic Article uri icon

Overview

MeSH Major

  • Kidney Failure, Chronic
  • Transforming Growth Factor beta1

abstract

  • End-stage renal disease (ESRD) is more frequent in African Americans (blacks) compared to whites. Because renal fibrosis is a correlate of progressive renal failure and a dominant feature of ESRD, and because transforming growth factor beta 1 (TGF-beta1) can induce fibrosis and renal insufficiency, we hypothesized that TGF-beta1 hyperexpression is more frequent in blacks compared to whites. We measured circulating levels of TGF-beta1 in black and white patients with ESRD, hypertension, and in normal patients. We demonstrated that circulating levels of TGF-beta1 are higher in black ESRD patients, hypertensive patients, and normal control patients compared to their white counterparts. Our preliminary genetic analyses suggest that TGF-beta1 DNA polymorphisms are different in blacks and whites. Our observations of hyperexpression of TGF-beta1 in blacks suggest a mechanism for the increased prevalence of renal failure and hypertensive target organ damage in this population.

publication date

  • December 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2744541

PubMed ID

  • 19768163

Additional Document Info

start page

  • 61

end page

  • 72

volume

  • 120