Biology of vascular malformations of the brain Review uri icon

Overview

MeSH Major

  • Cerebral Arteries
  • Genetic Predisposition to Disease
  • Intracranial Arteriovenous Malformations
  • Neovascularization, Pathologic

abstract

  • Recent findings begin to explain how mutations in VMB genes render vessels vulnerable to rupture when challenged with other inauspicious genetic or environmental factors and have suggested candidate therapeutics. Understanding of the cellular mechanisms of VMB formation and progression in humans has lagged behind that in animal models. New knowledge of lesion biology will spur new translational work. Several well-established clinical and genetic database efforts are already in place, and further progress will be facilitated by collaborative expansion and standardization of these.

publication date

  • December 2009

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2810509

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.109.563692

PubMed ID

  • 19834013

Additional Document Info

start page

  • e694

end page

  • 702

volume

  • 40

number

  • 12