Clinical states model for biomarkers in bladder cancer Review uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Urinary Bladder Neoplasms

abstract

  • Bladder cancer is a significant healthcare problem in the USA, with a high recurrence rate, the need for expensive continuous surveillance and limited treatment options for patients with advanced disease. Research has contributed to an understanding of the molecular pathways involved in the development and progression of bladder cancer, and that understanding has led to the discovery of potentially diagnostic, predictive and prognostic biomarkers. In this review, a clinical states model of bladder cancer is introduced and integrated into a paradigm for biomarker development. Biomarkers are systematically incorporated with predefined end points to aid in clinical management.

publication date

  • December 2009

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3705955

Digital Object Identifier (DOI)

  • 10.2217/fon.09.57

PubMed ID

  • 19792967

Additional Document Info

start page

  • 977

end page

  • 92

volume

  • 5

number

  • 7