Effect of peroxisome proliferator-activated receptor-α siRNA on hypertension and renal injury in the rat following nitric oxide withdrawal and high salt diet Academic Article uri icon

Overview

MeSH Major

  • Hypertension
  • Kidney
  • Nitric Oxide
  • PPAR alpha
  • RNA, Small Interfering
  • Sodium Chloride, Dietary

abstract

  • These data suggest that increased PPARalpha expression is a protective mechanism in hypertensive renal injury induced by nitric oxide withdrawal/high salt diet and that siRNAs targeting the DNA-binding domain of PPARalpha gene elicited differential effects on hypertension and kidney injury.

publication date

  • November 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/HJH.0b013e328330b6d9

PubMed ID

  • 19834340

Additional Document Info

start page

  • 2223

end page

  • 31

volume

  • 27

number

  • 11