Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors
Antineoplastic Combined Chemotherapy Protocols
Flavopiridol with FOLFOX is a safe and tolerable regimen. Promising clinical activity was seen across tumor types. Encouraging results in the platinum-refractory germ cell tumor population has prompted a phase II trial that is currently open for accrual.