Utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: Results from the CRUSADE quality improvement initiative Academic Article uri icon


MeSH Major

  • Angina, Unstable
  • Cardiac Catheterization
  • Myocardial Ischemia
  • Myocardial Revascularization
  • Outcome Assessment (Health Care)


  • Use of early invasive management within 48 hours of presentation, predictors of early invasive management, and in-hospital mortality. Results Of the 17,926 patients analyzed, 8037 (44.8%) underwent early cardiac catheterization less than 48 hours following presentation. Predictors of early invasive management included cardiology care, younger age, lack of prior or current congestive heart failure, lack of renal insufficiency, ischemic electrocardiographic changes, positive cardiac markers, white race, and male sex. Patients treated with early invasive management were more likely to be treated with medications and interventions recommended by the ACC/AHA guidelines and had a lower risk of in-hospital mortality after adjusting for differences in clinical characteristics and after comparing propensity-matched pairs (2.5% vs 3.7%, P<.001). Conclusions An early invasive management strategy is not utilized in the majority of high-risk patients with NSTE ACS. This strategy appears to be reserved for patients without significant comorbidities and those cared for by cardiologists and is associated with a lower risk of in-hospital mortality.

publication date

  • November 3, 2004



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1001/jama.292.17.2096

PubMed ID

  • 15523070

Additional Document Info

start page

  • 2096

end page

  • 104


  • 292


  • 17