Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis Academic Article uri icon

Overview

MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Anaphylaxis
  • Arthritis
  • Dermatitis
  • Phosphoproteins

abstract

  • Our data indicate that Y145 is the most critical tyrosine supporting SLP-76 function in myeloid cells. Future efforts to dissect how Y145 mediates SLP-76-dependent signaling in MCs and PMNs will increase our understanding of these lineages and provide insights into the treatment of allergy and inflammation.

publication date

  • November 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2778804

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2009.08.038

PubMed ID

  • 19895996

Additional Document Info

start page

  • 1088

end page

  • 98

volume

  • 124

number

  • 5