TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects Academic Article uri icon


MeSH Major

  • Alzheimer Disease
  • Antibodies
  • Periodontitis
  • Tumor Necrosis Factor-alpha


  • The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-alpha and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-alpha and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-alpha classification of clinical AD and NL. This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.

publication date

  • November 30, 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC2783848

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2009.08.013

PubMed ID

  • 19767111

Additional Document Info

start page

  • 92

end page

  • 7


  • 216


  • 1-2