Effects of the 5 alpha-reductase inhibitor dutasteride on gene expression in prostate cancer xenografts Academic Article uri icon

Overview

MeSH Major

  • Azasteroids
  • Cholestenone 5 alpha-Reductase
  • Enzyme Inhibitors
  • Neoplasm Transplantation
  • Prostatic Neoplasms
  • Transplantation, Heterologous

abstract

  • We have identified multiple pathways outside of the androgenic pathway in prostate cancer xenografts affected by treatment with dutasteride. These findings provide insights into the function of dutasteride within the tumor microenvironment, potentially allowing for development of agents that can be used in combination with this drug to further enhance its effectiveness.

publication date

  • December 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2783419

Digital Object Identifier (DOI)

  • 10.1002/pros.21022

PubMed ID

  • 19676081

Additional Document Info

start page

  • 1730

end page

  • 43

volume

  • 69

number

  • 16