Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics Academic Article uri icon

Overview

MeSH Major

  • Niemann-Pick Disease, Type C
  • Pyrroles

abstract

  • A five-step synthesis of an array of N-aryl-3-alkylidenepyrrolinones, which are potential Niemann-Pick type C (NPC) disease therapeutics, is described. The synthetic route allows for the production of analogues, including photoaffinity and biotinylated derivatives. Compound 1a increased esterification by acyl-coenzyme A:cholesteryl acyltransferase in NPC1 mutant cells. It also decreased LDL uptake and increased cholesterol efflux in both NPC1-deficient and normal cells.

publication date

  • October 22, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2791921

Digital Object Identifier (DOI)

  • 10.1021/jm900707n

PubMed ID

  • 19772346

Additional Document Info

start page

  • 6494

end page

  • 8

volume

  • 52

number

  • 20