Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts Academic Article uri icon

Overview

MeSH Major

  • Adenosine
  • Adenosine A1 Receptor Agonists
  • Cardiotonic Agents
  • Hyperhomocysteinemia
  • Ischemic Preconditioning, Myocardial

abstract

  • It may be concluded that the activation of adenosine-A1 receptors using CCPA markedly restored the suppressed cardioprotective and infarct size-limiting effects of IPC in hyperhomocysteinemic rat hearts. Thus, the reduced availability of extracellular adenosine and impaired activation of adenosine-A1 receptors may be responsible for abolishing the cardioprotective potential of IPC against I/R-induced myocardial injury in hyperhomocysteinemic rat hearts.

publication date

  • September 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/FJC.0b013e3181b04cc5

PubMed ID

  • 19568176

Additional Document Info

start page

  • 204

end page

  • 12

volume

  • 54

number

  • 3