Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement Academic Article uri icon

Overview

MeSH Major

  • Gene Rearrangement
  • HSP27 Heat-Shock Proteins
  • Prostatic Neoplasms
  • Proto-Oncogene Proteins c-ets

abstract

  • This study has confirmed that, in prostate cancers managed conservatively over a period of more than 15 years, expression of Hsp-27 is an accurate and independent predictive biomarker of aggressive disease with poor clinical outcome (P<0.001). These findings suggest that apoptotic and cell-migration pathways modulated by Hsp-27 may contain targets susceptible to the development of biologically appropriate chemotherapeutic agents that are likely to prove effective in treating aggressive prostate cancers.

publication date

  • August 26, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2768089

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6605227

PubMed ID

  • 19707199

Additional Document Info

start page

  • 1137

end page

  • 44

volume

  • 101

number

  • 7