Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization Academic Article uri icon

Overview

MeSH Major

  • Actins
  • Cholesterol
  • Lipoproteins, LDL
  • Macrophages

abstract

  • We describe a novel process that occurs during agLDL-macrophage interactions in which local release of free cholesterol causes local actin polymerization, promoting a pathological positive feedback loop for increased catabolism of agLDL and eventual foam cell formation.

publication date

  • October 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2755184

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.109.191882

PubMed ID

  • 19556523

Additional Document Info

start page

  • 1615

end page

  • 21

volume

  • 29

number

  • 10