Generation of pluripotent stem cells from patients with type 1 diabetes Academic Article uri icon

Overview

MeSH Major

  • Adult Stem Cells
  • Diabetes Mellitus, Type 1
  • Pluripotent Stem Cells

abstract

  • Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.

publication date

  • September 15, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2735559

Digital Object Identifier (DOI)

  • 10.1073/pnas.0906894106

PubMed ID

  • 19720998

Additional Document Info

start page

  • 15768

end page

  • 73

volume

  • 106

number

  • 37