Large Cell Neuroendocrine Carcinoma
Carcinoma, Large Cell
Carcinoma, Small Cell
This chapter reviews the current knowledge about the rare large cell neuroendocrine carcinoma (LCNEC) of the lung. LCNEC is an aggressive tumor most commonly encountered in elderly male smokers. Because of the difficulty in pathologic diagnosis, a surgical resection specimen is needed in most cases to make a definitive diagnosis. Little is known about the optimal therapy for patients with LCNEC. Although there is some suggestion that chemotherapeutic regimens used for small cell carcinoma may have some efficacy, this has not been proven. Unfortunately, these tumors are so rare that no single institution has enough cases to answer key questions regarding how these patients should be managed. An effort is under way to establish an International Registry of Pulmonary Neuroendocrine Tumors that will foster collaboration and more uniform approaches to diagnosis, management, and tracking response to therapy. © 2006 John Wiley & Sons, Ltd.
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