Docetaxel down-regulates the expression of androgen receptor and prostate-specific antigen but not prostate-specific membrane antigenin prostate cancer cell lines: Implications for PSA surrogacy Academic Article uri icon

Overview

MeSH Major

  • Antigens, Surface
  • Antineoplastic Agents
  • Glutamate Carboxypeptidase II
  • Prostate-Specific Antigen
  • Prostatic Neoplasms
  • Receptors, Androgen
  • Taxoids

abstract

  • While DOC did not affect PSMA expression, it was unexpectedly found to down-regulate AR and PSA. DOC-induced down-regulation of AR might be one of the anti-tumor mechanisms active in PC. Down-regulation of PSA may account for the significantly higher PSA response rates (45-50%) relative to measurable response rates (8-17%) reported in DOC PC trials and have implications for PSA surrogacy observations derived from DOC trials.

publication date

  • October 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/pros.21004

PubMed ID

  • 19575420

Additional Document Info

start page

  • 1579

end page

  • 85

volume

  • 69

number

  • 14