Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer Letter uri icon

Overview

MeSH Major

  • ABO Blood-Group System
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome-Wide Association Study
  • Pancreatic Neoplasms

abstract

  • We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

authors

publication date

  • September 2009

Research

keywords

  • Letter

Identity

Digital Object Identifier (DOI)

  • 10.1038/ng.429

PubMed ID

  • 19648918

Additional Document Info

start page

  • 986

end page

  • 90

volume

  • 41

number

  • 9