Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: Implications for diagnosis and monitoring drug therapy Academic Article uri icon

Overview

MeSH Major

  • Arthritis, Rheumatoid
  • Drug Monitoring
  • Lymphocytes

abstract

  • Phospho-flow analysis identified phosphorylation-activation of specific signaling effectors in the PB from patients with ERA. Notably, phosphorylation of these signaling effectors did not distinguish ERA from late RA, suggesting that the activation status of discrete cell populations is already established early in disease. However, when the ratio of MFI values for p-AKT and p-p38 is >1.5, there is a high likelihood of having a diagnosis of RA. Our results suggest that longitudinal sampling of patients undergoing therapy may result in phospho-signatures that are predictive of drug responsiveness.

publication date

  • August 20, 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2724743

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0006703

PubMed ID

  • 19693272

Additional Document Info

start page

  • e6703

volume

  • 4

number

  • 8