Neuropeptide Y1 Receptor NPY1R. Discovery of Naturally Occurring Human Genetic Variants Governing Gene Expression In Cella as Well as Pleiotropic Effects on Autonomic Activity and Blood Pressure In Vivo Academic Article uri icon

Overview

MeSH Major

  • Autonomic Nervous System
  • Blood Pressure
  • Gene Expression Regulation
  • Polymorphism, Genetic
  • Receptors, Neuropeptide Y

abstract

  • Our results indicate that naturally occurring genetic variation at the NPY1R locus has implications for heritable autonomic control of the circulation, and ultimately, for systemic hypertension. The findings suggest novel pathophysiological links between the NPY1R locus, autonomic activity, and blood pressure, and suggest new strategies to approach the mechanism, diagnosis, and treatment of systemic hypertension.

publication date

  • September 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2792636

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2009.05.035

PubMed ID

  • 19712806

Additional Document Info

start page

  • 944

end page

  • 54

volume

  • 54

number

  • 10