Pretreatment prostate-specific antigen (PSA) velocity and doubling time are associated with outcome but neither improves prediction of outcome beyond pretreatment PSA alone in patients treated with radical prostatectomy Academic Article uri icon


MeSH Major

  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Prostate-Specific Antigen
  • Prostatectomy
  • Prostatic Neoplasms


  • On univariate analysis, two of 12 PSADT and four of 10 PSAV definitions were univariately associated with both BCR and metastasis (P < .05). One PSADT and one PSAV definition had a higher predictive accuracy for BCR over PSA alone, and four PSAV definitions improved prediction of metastasis. However, the improvements in predictive accuracy were small, associated with wide CIs, and markedly reduced if additional predictors of stage and grade were included alongside PSA. Modeling with random variables suggests that similar results would be expected by chance. CONCLUSION We found no clear evidence that any definition of PSA dynamics substantially enhances the predictive accuracy of a single pretreatment PSA alone.

publication date

  • August 2009



  • Academic Article



  • eng

PubMed Central ID

  • PMC2720078

Digital Object Identifier (DOI)

  • 10.1200/JCO.2008.19.9794

PubMed ID

  • 19506163

Additional Document Info

start page

  • 3591

end page

  • 7


  • 27


  • 22