The left atrium, atrial fibrillation, and the risk of stroke in hypertensive patients with left ventricular hypertrophy Review uri icon


MeSH Major

  • Atrial Fibrillation
  • Hypertrophy, Left Ventricular
  • Stroke


  • The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study provided extensive data on predisposing factors, consequences, and prevention of atrial fibrillation (AF) in patients with hypertension and left ventricular (LV) hypertrophy. Randomized losartan-based treatment was superior to atenolol-based treatment for reducing new-onset AF and complications, especially stroke, associated with new-onset or pre-existing AF. Potential mechanisms of AF prevention by angiotensin receptor blockade supported by LIFE results include greater reduction in left atrial size and LV hypertrophy. Differential effects of antihypertensive treatment on the left atrium and left ventricle may help prevent AF and reduce risk of stroke associated with hypertensive heart disease.

publication date

  • December 11, 2008



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1177/1753944708093846

PubMed ID

  • 19124445

Additional Document Info

start page

  • 507

end page

  • 13


  • 2


  • 6