Radiosensitizing Effects of Temozolomide Observed in vivo only in a Subset of O6-Methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents, Alkylating
  • Brain Neoplasms
  • Dacarbazine
  • Glioblastoma
  • O(6)-Methylguanine-DNA Methyltransferase
  • Radiation-Sensitizing Agents

abstract

  • Concurrent treatment with TMZ and RT provides significant survival benefit only in a subset of MGMT methylated tumors and provides superior antitumor activity relative to sequential administration of RT and TMZ.

publication date

  • September 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2773462

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2009.04.026

PubMed ID

  • 19695438

Additional Document Info

start page

  • 212

end page

  • 9

volume

  • 75

number

  • 1