Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility Academic Article uri icon

Overview

MeSH Major

  • Cyclin-Dependent Kinase Inhibitor p15
  • DNA Helicases
  • Genetic Predisposition to Disease
  • Glioma
  • Polymorphism, Single Nucleotide

abstract

  • The causes of glioblastoma and other gliomas remain obscure. To discover new candidate genes influencing glioma susceptibility, we conducted a principal component-adjusted genome-wide association study (GWAS) of 275,895 autosomal variants among 692 adult high-grade glioma cases (622 from the San Francisco Adult Glioma Study (AGS) and 70 from the Cancer Genome Atlas (TCGA)) and 3,992 controls (602 from AGS and 3,390 from Illumina iControlDB (iControls)). For replication, we analyzed the 13 SNPs with P < 10(-6) using independent data from 176 high-grade glioma cases and 174 controls from the Mayo Clinic. On 9p21, rs1412829 near CDKN2B had discovery P = 3.4 x 10(-8), replication P = 0.0038 and combined P = 1.85 x 10(-10). On 20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x 10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9). For both SNPs, the direction of association was the same in discovery and replication phases.

publication date

  • August 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2923561

Digital Object Identifier (DOI)

  • 10.1038/ng.408

PubMed ID

  • 19578366

Additional Document Info

start page

  • 905

end page

  • 8

volume

  • 41

number

  • 8