Rejuvenation of the aging T cell compartment Review uri icon

Overview

MeSH Major

  • Aging
  • T-Lymphocytes

abstract

  • The elderly face significant risk for susceptibility to infection and cancer because of declining immune function. Various agents used in the setting of bone marrow transplantation and aging studies represent promising approaches to combating T cell defects in the aging population. Preclinical and clinical studies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these strategies may be used to alleviate the effects of T cell deficiencies in the elderly.

publication date

  • August 2009

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2731988

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2009.06.002

PubMed ID

  • 19608394

Additional Document Info

start page

  • 454

end page

  • 9

volume

  • 21

number

  • 4