Common genetic variants in candidate genes and risk of familial lymphoid malignancies Academic Article uri icon

Overview

MeSH Major

  • Lymphoproliferative Disorders
  • Polymorphism, Single Nucleotide

abstract

  • Familial aggregation, linkage and case-control studies support the role of germline genes in the aetiology of lymphoid malignancies. To further examine the role of genetic variation underlying susceptibility, we analysed 1536 single nucleotide polymorphisms in 152 genes involved in apoptosis, DNA repair, immune response and oxidative stress pathways among a unique sample of 165 unrelated familial cases including patients with chronic lymphocytic leukaemia (CLL), Waldenström macroglobulinaemia (WM) and Hodgkin lymphoma (HL), and 107 spouse controls. We confirmed previous studies showing a polymorphism in the IL10 promoter (rs1800890/-3575T>A) to be associated with non-Hodgkin lymphoma, as this allele was found to be associated with both CLL and WM. We also confirmed the role of IL6 variation to be associated with HL. Polymorphisms in TNFSF10 were associated with both CLL and WM. Future replication and functional studies are needed to clarify the role of these genetic variants. Finally, our data further support the close association of WM and CLL.

publication date

  • August 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2890251

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2141.2009.07790.x

PubMed ID

  • 19573080

Additional Document Info

start page

  • 418

end page

  • 23

volume

  • 146

number

  • 4