Phase i trial of weekly cisplatin, irinotecan and paclitaxel in patients with advanced gastrointestinal cancer
Antineoplastic Combined Chemotherapy Protocols
Maximum Tolerated Dose
Paclitaxel at 65 mg/m(2), cisplatin (30 mg/m(2)), and irinotecan (50 mg/m(2)) given weekly can be safely administered to patients with solid tumor malignancies. To improve cumulative toxicities, a schedule modification was required (3-week cycle; 2-on, 1-off) Neutropenia was the most common DLT. This combination showed substantial activity, particularly in patients with gastric and esophageal adenocarcinoma, and phase II evaluation could be considered.